Cytarabine (hydrochloride) (Standard)

Cytarabine (hydrochloride) (Standard) is the analytical standard of Cytarabine (hydrochloride) . This product is intended for research and analytical applications. Cytarabine hydrochloride, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine hydrochloride has antiviral effects against HSV.

Product Specifications

CAS Number

[69-74-9]

UNSPSC

12352100

Target

Autophagy; DNA/RNA Synthesis; HSV; Nucleoside Antimetabolite/Analog; Reference Standards

Related Pathways

Anti-infection; Autophagy; Cell Cycle/DNA Damage; Others

Field of Research

Cancer; Infection

Smiles

O=C1N=C(C=CN1[C@H]2[C@@H](O)[C@H](O)[C@@H](CO)O2)N.Cl

Molecular Formula

C9H14ClN3O5

Molecular Weight

279.68

References & Citations

[1]Tobias, S.C. and R.F. Borch, Synthesis and biological evaluation of a cytarabine phosphoramidate prodrug. Mol Pharm, 2004. 1 (2) : p. 112-6.|[2]Besirli, C.G., et al. Cytosine arabinoside rapidly activates Bax-dependent apoptosis and a delayed Bax-independent death pathway in sympathetic neurons. Cell Death Differ, 2003. 10 (9) : p. 1045-58.|[3]Yamauchi, H., et al., Involvement of p53 in 1-beta-D-arabinofuranosylcytosine-induced trophoblastic cell apoptosis and impaired proliferation in rat placenta. Biol Reprod, 2004. 70 (6) : p. 1762-7.|[4]Richel, D.J., et al., Comparison of the antileukaemic activity of 5 aza-2-deoxycytidine and arabinofuranosyl-cytosine in rats with myelocytic leukaemia. Br J Cancer, 1988. 58 (6) : p. 730-3.|[5]Shepshelovich D, et al. Pharmacodynamics of cytarabine induced leucopenia: a retrospective cohort study. Br J Clin Pharmacol. 2015 Apr;79 (4) :685-91.|[6]Renis HE. Antiviral activity of cytarabine in herpesvirus-infected rats. Antimicrob Agents Chemother. 1973 Oct;4 (4) :439-44.