Tetrazine-SS-PEG4-Biotin
Tetrazine-SS-PEG4-Biotin is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Tetrazine-SS-PEG4-Biotin is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
Product Specifications
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.42
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(CCSSCCNC(CCOCCOCCOCCOCCNC(CCCC[C@@H]1SC[C@H](N2)[C@@H]1NC2=O)=O)=O)NCC(C=C3)=CC=C3C4=NN=CN=N4
Molecular Formula
C35H53N9O8S3
Molecular Weight
824.05
Precautions
H302, H315, H319, H335
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker; Disulfide Cleavable Linker
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Recombinant Lactobacillus reuteri Uridine kinase (udk)
Recombinant Lactobacillus reuteri Uridine kinase (udk)
Recombinant Lactobacillus reuteri Uridine kinase (udk)
Recombinant Lactobacillus reuteri Uridine kinase (udk)
Recombinant Lactobacillus reuteri Uridine kinase (udk)