Cladribine-d4
Cladribine-d4 (2-Chloro-2′-deoxyadenosine-d4) is deuterium labeled Cladribine. Cladribine (2-Chloro-2′-deoxyadenosine), a purine nucleoside analog, is an orally active adenosine deaminase inhibitor. Cladribine functions as an inhibitor of DNA synthesis to block the repair of the damaged DNA. Cladribine can inhibit DNA methylation. Cladribine has anti-lymphoma activity. Cladribine can be used for the research of several hematologic malignancies and multiple sclerosis[1][2].
Product Specifications
Product Name Alternative
2-Chloro-2′-deoxyadenosine-d4; CldAdo-d4; 2CdA-d4
UNSPSC
12352005
Target
Isotope-Labeled Compounds
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cardiovascular Disease; Cancer
Smiles
OC([2H])([2H])[C@@H]1[C@H](C([2H])([2H])[C@@H](O1)N2C=NC3=C2N=C(N=C3N)Cl)O
Molecular Formula
C10H8D4ClN5O3
Molecular Weight
289.71
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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