2',5'-Dideoxyadenosine (Standard)
2',5'-Dideoxyadenosine (Standard) is the analytical standard of 2',5'-Dideoxyadenosine. This product is intended for research and analytical applications. 2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site with an IC50 of 3 µM . 2',5'-Dideoxyadenosine is a nucleoside analog and exerts a potent antiadrenergic action in heart[1][2].
Product Specifications
CAS Number
6698-26-6
UNSPSC
12352100
Target
Adenylate Cyclase; Adrenergic Receptor; Reference Standards
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Metabolic Disease
Smiles
C[C@@H]1[C@H](C[C@H](N2C=NC3=C(N=CN=C32)N)O1)O
Molecular Formula
C10H13N5O2
Molecular Weight
235.25
References & Citations
[1]Bushfield M, et al. Tissue levels, source, and regulation of 3'-AMP: an intracellular inhibitor of adenylyl cyclases. Mol Pharmacol. 1990 Dec;38 (6) :848-53.|[2]Hartmann M, et al. Isoproterenol antagonistic effect of 2',5'-dideoxyadenosine in the isolated perfused guinea-pig heart. J Mol Cell Cardiol. 1993 Mar;25 (3) :331-8.|[3]Zhao LX, et al. M1 muscarinic receptors regulate the phosphorylation of AMPA receptor subunit GluA1 via a signaling pathway linking cAMP-PKA and PI3K-Akt. FASEB J. 2019 May;33 (5) :6622-6631.|[4]Leme Tdos S, et al. Role of prostaglandin/cAMP pathway in the diuretic and hypotensive effects of purified fraction of Maytenus ilicifolia Mart ex Reissek (Celastraceae) . J Ethnopharmacol. 2013 Oct 28;150 (1) :154-61.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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