Desethyl chloroquine (diphosphate) (Standard)
Desethyl chloroquine (diphosphate) (Standard) is the analytical standard of Desethyl chloroquine (diphosphate) . This product is intended for research and analytical applications. Desethyl chloroquine diphosphate is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs) . Desethyl chloroquine diphosphate possesses antiplasmodic activity[1][2].
Product Specifications
CAS Number
247912-76-1
UNSPSC
12352100
Target
Autophagy; Parasite; Reference Standards; Toll-like Receptor (TLR)
Related Pathways
Anti-infection; Autophagy; Immunology/Inflammation; Others
Field of Research
Infection
Smiles
CC(NC1=CC=NC2=CC(Cl)=CC=C12)CCCNCC.O=P(O)(O)O.O=P(O)(O)O
Molecular Formula
C16H28ClN3O8P2
Molecular Weight
487.81
References & Citations
[1]Ajayi FO, et al. Comparison of the partitioning in vitro of chloroquine and its desethyl metabolites between the erythrocytes and plasma of healthy subjects and those with falciparum malaria. Afr J Med Med Sci. 1989 Jun;18 (2) :95-100.|[2]Vodicka P, et al. Assessment of chloroquine treatment for modulating autophagy flux in brain of WT and HD mice. J Huntingtons Dis. 2014;3 (2) :159-74.|[3]Said A, et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15;193 (12) :6135-43.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
Frequently Asked Questions
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