Iso-ADP ribose (TEA)

Iso-ADP ribose (isoADPr) TEA is a ligand used for protein nucleic acid modification. iso-ADP ribose TEA is a structure comprising parts of two consecutive ADP-ribosyl units within the PAR chain. iso-ADP ribose TEA is the small-molecule ligand for RING finger protein 146 (RNF146) WWE. A single iso-ADP ribose TEA molecule triggers the activation of RNF146 by interacting with the basic Lys61 residue in the RING domain[1][2].

Product Specifications

UNSPSC

12352005

Target

Fluorescent Dye

Related Pathways

Others

Field of Research

Others

Purity

99.97

Smiles

CCN(CC)CC.CCN(CC)CC.NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O[C@H]4[C@H](O)[C@H](O)[C@@H](COP(O)(O)=O)O4)[C@H](O)[C@@H](COP(O)(O)=O)O3

Molecular Formula

C27H53N7O14P2

Molecular Weight

761.70

References & Citations

[1]Kewen Peng, et al. Iso-ADP-Ribose Fluorescence Polarization Probe for the Screening of RNF146 WWE Domain Inhibitors. ACS Chem Biol. 2024 Feb 16;19 (2) :300-307.|[2]Federico Teloni, et al. Readers of poly (ADP-ribose) : designed to be fit for purpose. Nucleic Acids Res. 2016 Feb 18;44 (3) :993-1006.