Iso-ADP ribose (TEA)
Iso-ADP ribose (isoADPr) TEA is a ligand used for protein nucleic acid modification. iso-ADP ribose TEA is a structure comprising parts of two consecutive ADP-ribosyl units within the PAR chain. iso-ADP ribose TEA is the small-molecule ligand for RING finger protein 146 (RNF146) WWE. A single iso-ADP ribose TEA molecule triggers the activation of RNF146 by interacting with the basic Lys61 residue in the RING domain[1][2].
Product Specifications
UNSPSC
12352005
Target
Fluorescent Dye
Related Pathways
Others
Field of Research
Others
Purity
99.97
Smiles
CCN(CC)CC.CCN(CC)CC.NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O[C@H]4[C@H](O)[C@H](O)[C@@H](COP(O)(O)=O)O4)[C@H](O)[C@@H](COP(O)(O)=O)O3
Molecular Formula
C27H53N7O14P2
Molecular Weight
761.70
References & Citations
[1]Kewen Peng, et al. Iso-ADP-Ribose Fluorescence Polarization Probe for the Screening of RNF146 WWE Domain Inhibitors. ACS Chem Biol. 2024 Feb 16;19 (2) :300-307.|[2]Federico Teloni, et al. Readers of poly (ADP-ribose) : designed to be fit for purpose. Nucleic Acids Res. 2016 Feb 18;44 (3) :993-1006.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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