Diphenhydramine N-oxide

Diphenhydramine N-oxide is a metabolite of Diphenhydramine (HY-B0303) . Diphenhydramine is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine can across the ovine blood-brain barrier (BBB) [1][2][3][4].

Product Specifications

CAS Number

[3922-74-5]

UNSPSC

12352005

Target

Drug Metabolite

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Smiles

C[N+](C)([O-])CCOC(C1=CC=CC=C1)C2=CC=CC=C2

Molecular Formula

C17H21NO2

Molecular Weight

271.35

References & Citations

[1]Wong H, et al. Pharmacokinetics and renal excretion of diphenhydramine and its metabolites, diphenylmethoxyacetic acid and diphenhydramine-N-oxide, in developing lambs. J Pharm Sci. 2000 Oct;89 (10) :1362-70.|[2]Jason P Berninger, et al. Effects of the antihistamine diphenhydramine on selected aquatic organisms. Environ Toxicol Chem. 2011 Sep;30 (9) :2065-72. |[3]Föhr KJ, et al. Open channel block of NMDA receptors by diphenhydramine. Neuropharmacology. 2015 Dec;99:459-70. |[4]Ehling S, et al. Diphenhydramine pharmacokinetics after oral and intravenous administration of diphenhydramine and oral administration of dimenhydrinate to healthy dogs, and pharmacodynamic effect on histamine-induced wheal formation: a pilot study. Vet Dermatol. 2019 Apr;30 (2) :91-e24.