Bendamustine (Standard)
Bendamustine (Standard) is the analytical standard of Bendamustine. This product is intended for research and analytical applications. Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties[1].
Product Specifications
CAS Number
16506-27-7
UNSPSC
12352100
Target
Apoptosis; DNA Alkylator/Crosslinker; Reference Standards
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Others
Field of Research
Cancer
Smiles
O=C(O)CCCC1=NC2=CC(N(CCCl)CCCl)=CC=C2N1C
Molecular Formula
C16H21Cl2N3O2
Molecular Weight
358.26
References & Citations
[1]Leoni LM, et al. Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents. Clin Cancer Res. 2008 Jan 1;14 (1) :309-17.|[2]Cives M, et al. Bendamustine overcomes resistance to melphalan in myeloma cell lines by inducing cell death through mitotic catastrophe. Cell Signal. 2013 May;25 (5) :1108-17.|[3]Ackler S, et al. Navitoclax (ABT-263) and bendamustine ± rituximab induce enhanced killing of non-Hodgkin's lymphoma tumours in vivo. Br J Pharmacol. 2012 Oct;167 (4) :881-91.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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