Banoxantrone (dihydrochloride) (Standard)

Banoxantrone (dihydrochloride) (Standard) is the analytical standard of Banoxantrone (dihydrochloride) . This product is intended for research and analytical applications. Banoxantrone dihydrochloride is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor.

Product Specifications

CAS Number

[252979-56-9]

UNSPSC

12352100

Target

Reference Standards; Topoisomerase

Related Pathways

Cell Cycle/DNA Damage; Others

Field of Research

Cancer

Smiles

O=C1C2=C(C(O)=CC=C2O)C(C3=C(NCC[N+](C)(C)[O-])C=CC(NCC[N+](C)(C)[O-])=C13)=O.Cl.Cl

Molecular Formula

C22H30Cl2N4O6

Molecular Weight

517.40

References & Citations

[1]Hejmadi MV, et al. DNA damage following combination of radiation with the bioreductive drug AQ4N: possible selective toxicity to oxic and hypoxic tumour cells. Br J Cancer. 1996 Feb;73 (4) :499-505.|[2]Manley E Jr, et al. Impact of tumor blood flow modulation on tumor sensitivity to the bioreductive drug banoxantrone. J Pharmacol Exp Ther. 2013 Feb;344 (2) :368-77.|[3]Williams KJ, et al. In vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenografts. Mol Cancer Ther. 2009 Dec;8 (12) :3266-75.