β-Lapachone (Standard)

β-Lapachone (Standard) is the analytical standard of β-Lapachone. This product is intended for research and analytical applications. β-Lapachone (ARQ-501; NSC-26326) is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression.

Product Specifications

CAS Number

[4707-32-8]

UNSPSC

12352100

Target

Apoptosis; Autophagy; Indoleamine 2,3-Dioxygenase (IDO) ; Reference Standards; Topoisomerase

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others

Field of Research

Cancer

Smiles

O=C(C1=C2OC(C)(C)CC1)C(C3=C2C=CC=C3)=O

Molecular Formula

C15H14O3

Molecular Weight

242.27

References & Citations

[1]Li CJ, et al. beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin. J Biol Chem. 1993 Oct 25;268 (30) :22463-8.|[2]Vanni A, et al. DNA damage and cytotoxicity induced by beta-lapachone: relation to poly (ADP-ribose) polymerase inhibition. Mutat Res. 1998 Jun 5;401 (1-2) :55-63.|[3]Kim TW, et al. β-Lapachone enhances Mre11-Rad50-Nbs1 complex expression in cisplatin-induced nephrotoxicity. Pharmacol Rep. 2016 Feb;68 (1) :27-31.