Amsacrine (hydrochloride) (Standard)
Amsacrine (hydrochloride) (Standard) is the analytical standard of Amsacrine (hydrochloride) . This product is intended for research and analytical applications. Amsacrine hydrochloride (m-AMSA hydrochloride; acridinyl anisidide hydrochloride) is an inhibitor of topoisomerase II, and acts as an antineoplastic agent which can intercalates into the DNA of tumor cells.
Product Specifications
CAS Number
54301-15-4
UNSPSC
12352100
Target
Autophagy; Reference Standards; Topoisomerase
Related Pathways
Autophagy; Cell Cycle/DNA Damage; Others
Field of Research
Cancer
Smiles
CS(=O)(NC1=CC=C(NC2=C(C=CC=C3)C3=NC4=CC=CC=C42)C(OC)=C1)=O.[H]Cl
Molecular Formula
C21H20ClN3O3S
Molecular Weight
429.92
References & Citations
[1]Thomas D, et al. Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action. Br J Pharmacol. 2004 Jun;142 (3) :485-94.|[2]Attia SM. Molecular cytogenetic evaluation of the mechanism of genotoxic potential of amsacrine and nocodazole in mouse bone marrow cells. J Appl Toxicol. 2013 Jun;33 (6) :426-33.|[3]Kao-Shan CS, et al. Cytogenetic effects of amsacrine on human lymphocytes in vivo and in vitro. Cancer Treat Rep. 1984 Jul-Aug;68 (7-8) :989-97.|[4]Lee YC, et al. Amsacrine-induced apoptosis of human leukemia U937 cells is mediated by the inhibition of AKT- and ERK-induced stabilization of MCL1. Apoptosis. 2017 Mar;22 (3) :406-420.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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