RS-56812
RS-56812 is a partial agonist of the 5-HT3 receptor. RS-56812 significantly enhances the propulsive peristalsis of the colon. RS-56812 indirectly enhances cholinergic neurotransmission and improves the working memory performance of non-human primates. RS-56812 is used in research on diarrhea/colon peristalsis and cognitive disorders (such as Alzheimer's disease) [1][2].
Product Specifications
CAS Number
143137-35-3
UNSPSC
12352005
Target
5-HT Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(NC1CN2CCC1CC2)C(C3=CN(C)C4=C3C=CC=C4)=O
Molecular Formula
C18H21N3O2
Molecular Weight
311.38
References & Citations
[1]Terry AV Jr, et al. The 5-HT3 receptor antagonist, RS-56812, enhances delayed matching performance in monkeys. Neuroreport. 1996 Dec 20;8 (1) :49-54. |[2]Boakye PA, et al. 5-HT (3) and 5-HT (4) receptors contribute to the anti-motility effects of Garcinia buchananii bark extract in the guinea-pig distal colon. Neurogastroenterol Motil. 2012 Jan;24 (1) :e27-40.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT3 Receptor
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