A 131701
A 131701 is a selective α1a- (Ki: 0.22 nM for human α1a) and α1d-adrenoceptor antagonist. A 131701 antagonizes epinephrine-induced increases in intraurethral pressure (IUP) . A 131701 causes transient decreases in mean arterial blood pressure (MABP) and transient tachycardia. A 131701 can be used in the research of spontaneous hypertension[1].
Product Specifications
CAS Number
181490-18-6
UNSPSC
12352005
Target
Adrenergic Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Cardiovascular Disease
Smiles
O=C1NC(C2=NC=CC=C2S3)=C3C(N1CCN4C[C@]5([H])CCC6=C(OC)C=CC=C6[C@]5([H])C4)=O
Molecular Formula
C24H24N4O3S
Molecular Weight
448.54
References & Citations
[1]Hancock A A, et al. Pharmacological characterization of A‐131701, a novel α1‐adrenoceptor antagonist selective for α1A‐and α1D‐compared to α1B‐adrenoceptors[J]. Drug Development Research, 1998, 44 (4) : 140-162.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α adrenergic receptor
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