Nifurpirinol (Standard)

Nifurpirinol (P-7138) (Standard) is the analytical standard of Nifurpirinol (HY-135470) . This product is intended for research and analytical applications. Nifurpirinol (P-7138) is a selective prosubstrate of bacterial nitroreductase (NTR) . NTR catalyzes the reduction of nifurpirinol to generate cytotoxic metabolites that induce apoptosis in target cells. Nifurpirinol selectively ablates NTR-expressing cells such as pancreatic β cells, osteoblasts, dopaminergic neurons, and podocytes in transgenic zebrafish models. Nifurpirinol can be used in regeneration studies and disease modeling such as focal segmental glomerulosclerosis (FSGS) [1][2].

Product Specifications

CAS Number

[13411-16-0]

Product Name Alternative

P-7138 (Standard)

UNSPSC

12352005

Target

Bacterial; Reference Standards

Related Pathways

Anti-infection; Others

Field of Research

Infection

Smiles

OCC1=NC(/C=C/C2=CC=C([N+]([O-])=O)O2)=CC=C1

Molecular Formula

C12H10N2O4

Molecular Weight

246.22

References & Citations

[1]Bergemann D, et al. Nifurpirinol: A more potent and reliable substrate compared to metronidazole for nitroreductase-mediated cell ablations. Wound Repair Regen. 2018 Mar;26 (2) :238-244.|[2]Klawitter M, Siegerist F, Daniel S, et al. Nifurpirinol: A potent inducer of FSGS-like glomerular injury in transgenic zebrafish[J]