BQ-610

BQ-610 is a selective antagonist of the endothelin A receptor (ETA receptor) . BQ-610 specifically blocks the ETA receptor, competitively inhibiting the binding of endothelin-1 (ET-1) (a vasoconstrictive peptide) to the receptor, thereby blocking the effects of ET-1 such as vascular smooth muscle contraction, cell mitosis, and inhibition of hormone secretion. BQ-610 significantly alleviates cerebral vasospasm in rabbits. BQ-610 blocks the bronchial epithelial and pulmonary vascular cell proliferation caused by cigarette smoke in rat models. BQ-610 can delay the natural luteal regression in the cow's uterus. BQ-610 can be used for research on vasospasm, abnormal cell proliferation, and reproductive endocrine disorders[1][2][3].

Product Specifications

CAS Number

[141595-53-1]

UNSPSC

12352005

Target

Endothelin Receptor

Related Pathways

GPCR/G Protein

Field of Research

Endocrinology; Cardiovascular Disease

Smiles

O=C(O)[C@@H](CC1=CNC2=C1C=CC=C2)NC([C@@H](CC3=CN(C=O)C4=C3C=CC=C4)NC([C@H](CC(C)C)NC(N5CCCCCC5)=O)=O)=O

Molecular Formula

C36H44N6O6

Molecular Weight

656.77

References & Citations

[1]Keator CS, et al. Intrauterine infusion of BQ-610, an endothelin type A receptor antagonist, delays luteolysis in dairy heifers. Domest Anim Endocrinol. 2008 May;34 (4) :411-8. |[2]Cirak B, et al. The effects of endothelin antagonist BQ-610 on cerebral vascular wall following experimental subarachnoid hemorrhage and cerebral vasospasm. Clin Auton Res. 2004 Jun;14 (3) :197-201. |[3]Dadmanesh F, Wright JL. Endothelin-A receptor antagonist BQ-610 blocks cigarette smoke-induced mitogenesis in rat airways and vessels. Am J Physiol. 1997 Apr;272 (4 Pt 1) :L614-8.