PF-06422913

PF-06422913 is an orally active, potent and selective metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator[1].

Product Specifications

CAS Number

[1539296-46-2]

UNSPSC

12352005

Target

MGluR

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Inflammation/Immunology

Smiles

FC(F)(C1=C(C2=NN(C)C3=C2N=CC(OCC4=NC=CC=C4)=N3)C=NC=C1)F

Molecular Formula

C18H13F3N6O

Molecular Weight

386.33

References & Citations

[1]Falgun Shah, et al. Mechanisms of Skin Toxicity Associated with Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators. Cell Chem Biol. 2017 Jul 20;24 (7) :858-869.e5.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MGluR5

Curated Selection

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