Quilostigmine

Quilostigmine (HP-290) is an orally active Physostigmine analogue, acetylcholinesterase (IC50: 148 nM for rat brain acetylcholinesterase) inhibitor. Quilostigmine has a long-lasting effect on tremors. Quetiapine can be used in the research of Alzheimer's disease[1][2].

Product Specifications

CAS Number

139314-01-5

Product Name Alternative

HP-290; NXX-066

UNSPSC

12352005

Target

Cholinesterase (ChE) ; Drug Derivative

Related Pathways

Neuronal Signaling; Others

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

O=C(N1CC2=C(C=CC=C2)CC1)OC3=CC4=C(N(C)[C@]5([H])[C@@]4(C)CCN5C)C=C3

Molecular Formula

C23H27N3O2

Molecular Weight

377.48

References & Citations

[1]Dahlin M, Björk E. Nasal administration of a physostigmine analogue (NXX-066) for Alzheimer's disease to rats. Int J Pharm. 2001 Jan 16;212 (2) :267-74. |[2]Snape MF, et al. A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066. Neuropharmacology. 1999 Jan;38 (1) :181-93.