(S) -Verapamil (hydrochloride) -d6

(S) -Verapamil-d6 ((S) - (-) -Verapamil-d6) hydrochloride is the deuterium labeled (S) -Verapamil hydrochloride. (S) -Verapamil hydrochloride (S (-) -Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S) -Verapamil hydrochloride leads to the death of potentially resistant tumor cells[1][2].

Product Specifications

CAS Number

[1329611-24-6]

Product Name Alternative

(S) - (-) -Verapamil (hydrochloride) -d6

UNSPSC

12352005

Target

Apoptosis; Calcium Channel; Isotope-Labeled Compounds; Leukotriene Receptor

Related Pathways

Apoptosis; GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Field of Research

Cancer

Solubility

10 mM in DMSO

Smiles

COC(C=C1CCN(C)CCC[C@@](C#N)(C2=CC(OC)=C(C=C2)OC)C(C([2H])([2H])[2H])C([2H])([2H])[2H])=C(C=C1)OC.Cl

Molecular Formula

C27H33D6ClN2O4

Molecular Weight

497.10

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Perrotton T, et al. (R) - and (S) -verapamil differentially modulate the multidrug-resistant protein MRP1. J Biol Chem. 2007 Oct 26;282 (43) :31542-8. Epub 2007 Jul 22.|[3]Tannergren C, et al. St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism. Clin Pharmacol Ther. 2004 Apr;75 (4) :298-309.