DMPEN

DMPEN (NSC 682691) (4-Demethylpenclomedine) is an alkylating metabolite of Penclomedine (HY-106401) . DMPEN has an antitumor activity. DMPEN does not induce Purkinje cells loss with no significant neurocerebellar toxicity in rat cerebellum models. DMPEN can be used for cancers like breast and brain cancer research[1].

Product Specifications

CAS Number

[176046-79-0]

Product Name Alternative

NSC 682691; 4-Demethylpenclomedine

UNSPSC

12352005

Target

Drug Metabolite

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

ClC1=C(OC)N=C(C(Cl)(Cl)Cl)C(Cl)=C1O

Molecular Formula

C7H4Cl5NO2

Molecular Weight

311.38

References & Citations

[1]O'Reilly S, et al. The alkylating agent penclomedine induces degeneration of purkinje cells in the rat cerebellum. Invest New Drugs. 2003 Aug;21 (3) :269-79.|[2]Waud WR, et al. 4-Demethylpenclomedine, an antitumor-active, potentially nonneurotoxic metabolite of penclomedine. Cancer Res. 1997 Mar 1;57 (5) :815-7.