DMPEN
DMPEN (NSC 682691) (4-Demethylpenclomedine) is an alkylating metabolite of Penclomedine. DMPEN has an antitumor activity. DMPEN does not induce Purkinje cells loss with no significant neurocerebellar toxicity in rat cerebellum models. DMPEN can be used for cancers like breast and brain cancer research[1].
Product Specifications
CAS Number
176046-79-0
Product Name Alternative
NSC 682691; 4-Demethylpenclomedine
UNSPSC
12352005
Target
Drug Metabolite
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
ClC1=C(OC)N=C(C(Cl)(Cl)Cl)C(Cl)=C1O
Molecular Formula
C7H4Cl5NO2
Molecular Weight
311.38
References & Citations
[1]O'Reilly S, et al. The alkylating agent penclomedine induces degeneration of purkinje cells in the rat cerebellum. Invest New Drugs. 2003 Aug;21 (3) :269-79.|[2]Waud WR, et al. 4-Demethylpenclomedine, an antitumor-active, potentially nonneurotoxic metabolite of penclomedine. Cancer Res. 1997 Mar 1;57 (5) :815-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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