Emavusertib (maleate)
Emavusertib maleate (CA-4948 maleate) is the maleate salt form of Emavusertib. Emavusertib maleate is an orally active inhibitor for IRAK4 (IC50=57 nM) and FLT3. Emavusertib maleate inhibits NF-κB and MyD88 signaling pathways, reduces the generation of pro-inflammatory cytokines like IL-6 and IL-10, thereby exhibiting anti-inflammatory and anti-proliferative activities against cancer cells, leading to cell apoptosis. Emavusertib maleate exhibits antitumor activity in mouse model[1][2][3].
Product Specifications
CAS Number
2376399-39-0
Product Name Alternative
CA-4948 (maleate)
UNSPSC
12352005
Target
Apoptosis; FLT3; IRAK; MyD88; NF-κB
Related Pathways
Apoptosis; Immunology/Inflammation; NF-κB; Protein Tyrosine Kinase/RTK
Field of Research
Cancer; Inflammation/Immunology
Smiles
OC(/C=C\C(O)=O)=O.O=C(C1=COC(C2=CC=NC(C)=C2)=N1)NC3=C(N4CC[C@H](C4)O)N=C5C(OC(N6CCOCC6)=N5)=C3
Molecular Formula
C28H29N7O9
Molecular Weight
607.57
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Frequently Asked Questions
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