BCL-XL-IN-4
BCL-XL-IN-4 (compound 10) is a potent and selective BCL-XL inhibitor with Ki values of 0.042, 170 nM for BCL-XL, BCL-2, respectively. BCL-XL-IN-4 shows cytotoxicity[1].
Product Specifications
CAS Number
[1235033-39-2]
UNSPSC
12352005
Target
Bcl-2 Family
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
O=C(C1=C(CCOC2=CC=C(N3N=CC4=CN=CN=C43)C=C2)SC(N5CC6=C(C=CC=C6C(NC7=NC8=CC=CC=C8S7)=O)CC5)=N1)O
Molecular Formula
C34H26N8O4S2
Molecular Weight
674.75
References & Citations
[1]Tao ZF, et al. Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity. ACS Med Chem Lett. 2014 Aug 26;5 (10) :1088-93.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2; Bcl-xL
Curated Selection
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