AG-1478 (Standard)
AG-1478 (Standard) is the analytical standard of AG-1478. This product is intended for research and analytical applications. AG-1478 (Tyrphostin AG-1478) is a selective EGFR tyrosine kinase inhibitor with IC50 of 3 nM. AG-1478 has antiviral effects against HCV and encephalomyocarditis virus (EMCV) .
Product Specifications
CAS Number
153436-53-4
UNSPSC
12352100
Target
EGFR; HCV; Influenza Virus; Reference Standards
Related Pathways
Anti-infection; JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer; Infection; Metabolic Disease; Cardiovascular Disease
Smiles
COC1=CC2=NC=NC(NC3=CC=CC(Cl)=C3)=C2C=C1OC
Molecular Formula
C16H14ClN3O2
Molecular Weight
315.75
References & Citations
[1]Bojko A, et al. The effect of tyrphostins AG494 and AG1478 on the autocrine growth regulation of A549 and DU145 cells. Folia Histochem Cytobiol. 2012 Jul 5;50 (2) :186-95.|[2]Li W, et al. EGFR Inhibition Blocks Palmitic Acid-induced inflammation in cardiomyocytes and Prevents Hyperlipidemia-induced Cardiac Injury in Mice. Sci Rep. 2016 Apr 18;6:24580.|[3]Akhtar S, et al. Cationic Polyamidoamine Dendrimers as Modulators of EGFR Signaling In Vitro and In Vivo. PLoS One. 2015 Jul 13;10 (7) :e0132215.|[4]Dorobantu CM, et al. Tyrphostin AG1478 Inhibits Encephalomyocarditis Virus and Hepatitis C Virus by Targeting Phosphatidylinositol 4-Kinase IIIα. Antimicrob Agents Chemother. 2016 Sep 23;60 (10) :6402-6.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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