PAC-1-d8

PAC-1-d8 (Procaspase activating compound 1-d8) is the deuterium labeled PAC-1 (HY-13523) . PAC-1 is a procaspase-3 activator that induces apoptosis in cancer cells with an EC50 of 2.08 μM.

Product Specifications

CAS Number

[1287241-26-2]

Product Name Alternative

Procaspase activating compound 1-d8

UNSPSC

12352005

Target

Apoptosis; Autophagy; Caspase; Isotope-Labeled Compounds

Related Pathways

Apoptosis; Autophagy; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

[2H]C1([2H])C([2H])([2H])N(CC2=CC=CC=C2)C([2H])([2H])C([2H])([2H])N1CC(N/N=C/C3=C(C(CC=C)=CC=C3)O)=O

Molecular Formula

C23H20D8N4O2

Molecular Weight

400.54

References & Citations

[1]Wang F, et al. A novel small-molecule activator of procaspase-3 induces apoptosis in cancer cells and reduces tumor growth in human breast, liver and gallbladder cancer xenografts. Mol Oncol. 2014 Dec;8 (8) :1640-52.|[2]Seervi M, et al. ERO1α-dependent endoplasmic reticulum-mitochondrial calcium flux contributes to ER stress and mitochondrial permeabilization by procaspase-activating compound-1 (PAC-1) . Cell Death Dis. 2013 Dec 19;4:e968.|[3]Putt KS, et al. Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat Chem Biol. 2006 Oct;2 (10) :543-50.