Ethacizine (hydrochloride) (Standard)

Ethacizine (hydrochloride) (Standard) is the analytical standard of Ethacizine (hydrochloride) . This product is intended for research and analytical applications. Ethacizine hydrochloride (Ethacizin; NIK-244) is a longer-lasting Class Ic antiarrhythmic agent than Flecainide[1]. Ethacizine hydrochloride (Ethacizin; NIK-244) inhibits the depolarizing current responsible for the intraatrial and His-Purkinje-ventricular conduction[2].

Product Specifications

CAS Number

[57530-40-2]

UNSPSC

12352100

Target

Reference Standards; Sodium Channel

Related Pathways

Membrane Transporter/Ion Channel; Others

Field of Research

Cardiovascular Disease

Smiles

O=C(OCC)NC(C=C1N2C(CCN(CC)CC)=O)=CC=C1SC3=C2C=CC=C3.[H]Cl

Molecular Formula

C22H28ClN3O3S

Molecular Weight

449.99

References & Citations

[1]Sugiyama A, et al. Comparison of cardiovascular effects of a novel class Ic antiarrhythmic agent, NIK-244, with those of flecainide in isolated canine heart preparations cross-circulated with a donor dog.Jpn J Pharmacol. 1991 May;56 (1) :1-12.|[2]Satoh H, et al. An electrophysiological comparison of a novel class Ic antiarrhythmic agent, NIK-244 (ethacizin) and flecainide in canine ventricular muscle.Br J Pharmacol. 1989 Nov;98 (3) :827-32.Med Chem. 2019 Nov 6:115132.