Cutamesine dihydrochloride (Standard)
Cutamesine dihydrochloride (Standard) is the analytical standard of Cutamesine dihydrochloride. This product is intended for research and analytical applications. Cutamesine dihydrochloride (SA4503 dihydrochloride; AGY94806 dihydrochloride) is a potent Sigma 1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes.
Product Specifications
CAS Number
165377-44-6
UNSPSC
12352100
Target
Reference Standards; Sigma Receptor
Related Pathways
Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
COC1=CC=C(CCN2CCN(CCCC3=CC=CC=C3)CC2)C=C1OC.Cl.Cl
Molecular Formula
C23H34Cl2N2O2
Molecular Weight
441.43
References & Citations
[1]Lever JR, et al. Sigma1 and sigma2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503. Synapse. 2006 May;59 (6) :350-8.|[2]Tuerxun T, et al. SA4503, a sigma-1 receptor agonist, prevents cultured cortical neurons from oxidative stress-induced cell death via suppression of MAPK pathway activation and glutamate receptor expression. Neurosci Lett. 2010 Jan 29;469 (3) :303-8.|[3]Minabe Y, et al. Acute and chronic administration of the selective sigma1 receptor agonist SA4503 significantly alters the activity of midbrain dopamine neurons in rats: An in vivo electrophysiological study. Synapse. 1999 Aug;33 (2) :129-40.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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