Mitoxantrone-d8 (hydrochloride)

Mitoxantrone-d8 (hydrochloride) (Mitozantrone-d8 (hydrochloride) ) is deuterium labeled Mitoxantrone (dihydrochloride) . Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity[1][2][3][4]. Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively[5].

Product Specifications

Product Name Alternative

Mitozantrone-d8 (hydrochloride) ; NSC 301739-d8 (hydrochloride)

UNSPSC

12352005

Target

Apoptosis; Endogenous Metabolite; Isotope-Labeled Compounds; Orthopoxvirus; PKC; Topoisomerase

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; Others; TGF-beta/Smad

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Smiles

O=C1C2=C(C(C3=C1C(NCCNC([2H])([2H])C([2H])([2H])O)=CC=C3NCCNC([2H])([2H])C([2H])([2H])O)=O)C(O)=CC=C2O.Cl

Molecular Formula

C22H21D8ClN4O6

Molecular Weight

488.99

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Venza I, et al. Class II-specific histone deacetylase inhibitors MC1568 and MC1575 suppress IL-8 expression in human melanoma cells. Pigment Cell Melanoma Res. 2013 Mar;26 (2) :193-204.|[3]Fujimoto S, et al. Antitumor activity of mitoxantrone against murine experimental tumors: comparative analysis against various antitumor antibiotics. Cancer Chemother Pharmacol. 1982;8 (2) :157-62.|[4]Takeuchi N, et al. Inhibitory effect of mitoxantrone on activity of protein kinase C and growth of HL60 cells. J Biochem. 1992 Dec;112 (6) :762-7.|[5]Bellosillo B, et al. Mitoxantrone, a topoisomerase II inhibitor, induces apoptosis of B-chronic lymphocytic leukaemia cells. Br J Haematol. 1998 Jan;100 (1) :142-6.|[6]Sharon E Altmann, et al. Inhibition of cowpox virus and monkeypox virus infection by mitoxantrone. Antiviral Res. 2012 Feb;93 (2) :305-308.