3'-Deoxy-GTP

3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate), an analog of GTP, is a RNA chain terminator and suppresses RNA synthesis. 3'-Deoxy-GTP inhibits DENV NS5 RdRp (IC50: 0.02 μM) [1][2].

Product Specifications

CAS Number

[55968-37-1]

Product Name Alternative

3′-Deoxyguanosine 5′-triphosphate

UNSPSC

12352005

Target

Dengue Virus; DNA/RNA Synthesis; Nucleoside Antimetabolite/Analog

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Field of Research

Infection

Smiles

O=C1C2=C(N([C@H]3[C@H](O)C[C@@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)O3)C=N2)NC(N)=N1

Molecular Formula

C10H16N5O13P3

Molecular Weight

507.18

References & Citations

[1]Yin Z, et al. An adenosine nucleoside inhibitor of dengue virus. Proc Natl Acad Sci U S A. 2009 Dec 1;106 (48) :20435-9.|[2]Oliveira AF, et al. Potential Antivirals: Natural Products Targeting Replication Enzymes of Dengue and Chikungunya Viruses. Molecules. 2017 Mar 22;22 (3) :505.