JNJ-28312141 (hydrochloride)

JNJ-28312141 hydrochloride is an inhibitor for colony-stimulating factor-1 receptor (CSF-1R or FMS), with an IC50 of 0.69 nM. JNJ-28312141 hydrochloride inhibits proliferation of BDBM, MV-4-11, M-o7e, TF-1 with an IC50s of 2.6, 21, 41 and 150 nM, respectively. JNJ-28312141 hydrochloride exhibits anti-inflammatory activity in mouse arthritis model[1].

Product Specifications

CAS Number

[1149939-55-8]

UNSPSC

12352005

Target

C-Fms

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Smiles

O=C(C1=NC(C#N)=CN1)NC2=C(C3=CCCCC3)C=C(C4CCN(C(CN(C)C)=O)CC4)C=C2.Cl

Molecular Formula

C26H33ClN6O2

Molecular Weight

497.03

References & Citations

[1]Illig CR, et al., Optimization of a potent class of arylamide colony-stimulating factor-1 receptor inhibitors leading to anti-inflammatory clinical candidate 4-cyano-N-[2- (1-cyclohexen-1-yl) -4-[1-[ (dimethylamino) acetyl]-4-piperidinyl]phenyl]-1H-imidazole-2-carboxamide (JNJ-28312141) . J Med Chem. 2011 Nov 24;54 (22) :7860-83.