LW106
LW106 is a selective IDO1 inhibitor with an IC50 of 1.57 μM. LW106 has no inhibitory effect on IDO2 and TDO. LW106 inhibits tumor outgrowth by limiting stroma-immune crosstalk and CSC enrichment in the tumor microenvironment. LW106 reduces subpopulation of cancer stem cells (CSCs) in xenografted tumors in which less proliferative/invasive tumor cells and more tumor cells apoptosis. LW106 can be used for the studies of lung cancer and melanoma[1].
Product Specifications
CAS Number
2116519-76-5
UNSPSC
12352005
Target
Apoptosis; Indoleamine 2,3-Dioxygenase (IDO) ; SWI/SNF Complex
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O/N=C(N1CC2=C(C1)C=CC=C2)/C3=NON=C3N
Molecular Formula
C11H11N5O2
Molecular Weight
245.24
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IDO1
Frequently Asked Questions
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