GSK8470

GSK8470 (Compound 5a) is an LRH-1 (EC50 = 0.43 μM) /SF-1 agonist (EC50 = 0.054 μM) . GSK8470 increases the expression of small heterodimer chaperones (SHPs), a target gene of LRH-1, in hepatocytes[1][2].

Product Specifications

CAS Number

[1276664-65-3]

UNSPSC

12352005

Target

Orphan Nuclear Receptor

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Smiles

CCC/C=C(CCC)/C(C[C@@]1([H])CCC2)=C(C3=CC=CC=C3)[C@@]12NC4=CC=CC=C4

Molecular Formula

C28H35N

Molecular Weight

385.58

References & Citations

[1]Whitby RJ, et al. Identification of small molecule agonists of the orphan nuclear receptors liver receptor homolog-1 and steroidogenic factor-1. J Med Chem. 2006 Nov 16;49 (23) :6652-5.|[2]Mays SG, et al. Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists. J Biol Chem. 2016 Dec 2;291 (49) :25281-25291.