AS1940477

AS1940477 (Compound 3f) is an orally active p38 MAPK inhibitor. AS1940477 inhibits the enzymatic activity of recombinant p38α and β isoforms. AS1940477 inhibits the production of pro-inflammatory cytokines (including TNFα, IL-1β, and IL-6) in human synovial interstitial cells and animal models of inflammation. AS1940477 can be used in research on inflammatory diseases[1][2].

Product Specifications

CAS Number

[928344-12-1]

UNSPSC

12352005

Target

Interleukin Related; p38 MAPK; TNF Receptor

Related Pathways

Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

OC[C@H]1CN2C(NC1)=C(C3=NN(C4=C(C=CC=C4)C)C(C=C3)=O)C(C5=CC=C(C=C5)F)=N2

Molecular Formula

C24H22FN5O2

Molecular Weight

431.46

References & Citations

[1]Asano T, Yet al. Identification, synthesis, and biological evaluation of 6-[ (6R) -2- (4-fluorophenyl) -6- (hydroxymethyl) -4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2- (2-methylphenyl) pyridazin-3 (2H) -one (AS1940477), a potent p38 MAP kinase inhibitor. J Med Chem. 2012 Sep 13;55 (17) :7772-85.|[2]Terajima M, et al. Anti-inflammatory effect and selectivity profile of AS1940477, a novel and potent p38 mitogen-activated protein kinase inhibitor. Eur J Pharmacol. 2013 Jan 5;698 (1-3) :455-62.