AS1940477
AS1940477 (Compound 3f) is an orally active p38 MAPK inhibitor. AS1940477 inhibits the enzymatic activity of recombinant p38α and β isoforms. AS1940477 inhibits the production of pro-inflammatory cytokines (including TNFα, IL-1β, and IL-6) in human synovial interstitial cells and animal models of inflammation. AS1940477 can be used in research on inflammatory diseases[1][2].
Product Specifications
CAS Number
928344-12-1
UNSPSC
12352005
Target
Interleukin Related; p38 MAPK; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
OC[C@H]1CN2C(NC1)=C(C3=NN(C4=C(C=CC=C4)C)C(C=C3)=O)C(C5=CC=C(C=C5)F)=N2
Molecular Formula
C24H22FN5O2
Molecular Weight
431.46
References & Citations
[1]Asano T, Yet al. Identification, synthesis, and biological evaluation of 6-[ (6R) -2- (4-fluorophenyl) -6- (hydroxymethyl) -4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2- (2-methylphenyl) pyridazin-3 (2H) -one (AS1940477), a potent p38 MAP kinase inhibitor. J Med Chem. 2012 Sep 13;55 (17) :7772-85.|[2]Terajima M, et al. Anti-inflammatory effect and selectivity profile of AS1940477, a novel and potent p38 mitogen-activated protein kinase inhibitor. Eur J Pharmacol. 2013 Jan 5;698 (1-3) :455-62.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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