(R) -AM-1638

(R) -AM-1638 is a R-isomer of AM-1638 (HY-13467) . AM-1638 is an orally active full agonist of GPR40 (EC50: 0.16 μM) [1][2][3].

Product Specifications

CAS Number

[1142222-18-1]

UNSPSC

12352005

Target

Free Fatty Acid Receptor

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cardiovascular Disease; Metabolic Disease

Smiles

FC1=CC=C(OC)C=C1C2=C(C3=CCCC3(C)C)C=C(C=C2)COC4=CC([C@@H](C5CC5)CC(O)=O)=CC=C4

Molecular Formula

C33H35FO4

Molecular Weight

514.63

References & Citations

[1]Hwang HJ, et al. AM1638, a GPR40-Full Agonist, Inhibited Palmitate- Induced ROS Production and Endoplasmic Reticulum Stress, Enhancing HUVEC Viability in an NRF2-Dependent Manner. Endocrinol Metab (Seoul) . 2023 Dec;38 (6) :760-769.|[2]Brown SP, et al. Discovery of AM-6226: A Potent and Orally Bioavailable GPR40 Full Agonist That Displays Efficacy in Nonhuman Primates. ACS Med Chem Lett. 2018 Jun 6;9 (7) :757-760.|[3]Brown SP, et al. Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist. ACS Med Chem Lett. 2012 Aug 15;3 (9) :726-30.