Dioctatin A (hydrochloride)

Dioctatin A hydrochloride is a metabolite of Streptomyces and an inhibitor of human dipeptidyl aminopeptidase II. Dioctatin A hydrochloride can inhibit aflatoxin production by Aspergillus parasiticus with an IC50 of 4.0 μM. Dioctatin A hydrochloride can reduce the mRNA levels of aflatoxin biosynthetic genes and the regulatory gene aflR, inhibit conidiation and decrease the mRNA level of the brlA gene, and also promote kojic acid production. In addition, Dioctatin A hydrochloride can inhibit sterigmatocystin production. Dioctatin A hydrochloride has pleiotropic regulatory effects on the production and differentiation of fungal secondary metabolites[1].

Product Specifications

UNSPSC

12352211

Target

Bacterial; Dipeptidyl Peptidase; Fungal

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Infection

Smiles

O=C(C[C@@H](NC([C@@H]([C@H](CCCCC)N)C)=O)CCCCC)N/C(C(O)=O)=C/C.Cl

Molecular Formula

C21H40ClN3O4

Molecular Weight

434.01

References & Citations

[1]Yoshinari T, et al. Dioctatin A is a strong inhibitor of aflatoxin production by Aspergillus parasiticus. Microbiology (Reading) . 2007 Aug;153 (Pt 8) :2774-2780.