SM-102-d4

SM-102-d4 is the deuterium labeled SM-102 (HY-134541) . SM-102 is an amino cationic lipid useful in the formation of lipid nanoparticles (LNPs) . SM-102 has higher transfection efficiency. SM-102 plays an important role in the effectiveness of lipid nanoparticles (LNPs) in delivering mRNA therapeutics and vaccines[1][2].

Product Specifications

UNSPSC

12352211

Target

Isotope-Labeled Compounds; Liposome

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Infection

Smiles

O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(C([2H])([2H])C([2H])([2H])O)CCCCCC(OCCCCCCCCCCC)=O

Molecular Formula

C44H83D4NO5

Molecular Weight

714.19

References & Citations

[1]Escalona-Rayo O, et al. In vitro and in vivo evaluation of clinically-approved ionizable cationic lipids shows divergent results between mRNA transfection and vaccine efficacy. Biomed Pharmacother. 2023 Sep;165:115065. |[2]Cho HY, et al. Effective Perturbations on the Amplitude and Hysteresis of Erg-Mediated Potassium Current Caused by 1-Octylnonyl 8-[ (2-hydroxyethyl) [6-oxo-6 (undecyloxy) hexyl]amino]-octanoate (SM-102), a Cationic Lipid. Biomedicines. 2021 Oct 1;9 (10) :1367.