Bis-Cl-ANT-ATP (tetrasodium)
Bis-Cl-ANT-ATP (tetrasodium) is a fluorescent ATP derivative, which undergo spontaneous isomerization. Bis-Cl-ANT-ATP (tetrasodium) selectively inhibits B. pertussis Adenylyl Cyclase (AC) toxin CyaA over mammalian AC1, AC2, and AC5 (Kis = 16, 1,700, 2,400, and 1,600 nM, respectively) . Bis-Br-ANT-ATP (tetrasodium) can be used in the study of whooping cough[1].
Product Specifications
UNSPSC
12352005
Target
Adenylate Cyclase; Bacterial
Related Pathways
Anti-infection; GPCR/G Protein
Field of Research
Infection
Smiles
NC(N=CN=C12)=C1N=CN2[C@@H]3O[C@H](COP(OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O)[C@@H](OC(C4=C(C=CC(Cl)=C4)N)=O)[C@H]3OC(C5=C(C=CC(Cl)=C5)N)=O
Molecular Formula
C24H20Cl2N7Na4O15P3
Molecular Weight
902.24
References & Citations
[1]Geduhn J, et al. Bis-halogen-anthraniloyl-substituted nucleoside 5'-triphosphates as potent and selective inhibitors of Bordetella pertussis adenylyl cyclase toxin. J Pharmacol Exp Ther. 2011 Jan;336 (1) :104-15.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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