ATP-γ-S (tetrasodium)

ATP-γ-S (tetrasodium) is a P2Y11 receptor agonist, an antioxidant and a neuroprotective agent. ATP-γ-S (tetrasodium) can be used as a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. ATP-γ-S (tetrasodium) is active in ATP hydrolysis[1][2][3][4][5].

Product Specifications

CAS Number

[88453-52-5]

UNSPSC

12352005

Target

Eukaryotic Initiation Factor (eIF) ; P2Y Receptor

Related Pathways

Cell Cycle/DNA Damage; GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology; Neurological Disease

Solubility

10 mM in DMSO

Smiles

O[C@@H]([C@H]([C@@](N1C=NC2=C1N=CN=C2N)([H])O3)O)[C@H]3COP(OP(OP(O[Na])(S[Na])=O)(O[Na])=O)(O[Na])=O

Molecular Formula

C10H12N5Na4O12P3S

Molecular Weight

611.17

References & Citations

[1]Ortal Danino, et al. ATP-γ-S- (α, β-CH2) protects against oxidative stress and amyloid beta toxicity in neuronal culture. Biochem Biophys Res Commun. 2015 May 1;460 (2) :446-50. |[2]J W Lee, et al. Inhibition of recA protein promoted ATP hydrolysis. 1. ATP gamma S and ADP are antagonistic inhibitors. Biochemistry. 1990 Aug 21;29 (33) :7666-76.|[3]Matthew L Peck, et al. Adenosine 5'-O- (3-thio) triphosphate (ATPgammaS) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. RNA. 2003 Oct;9 (10) :1180-7.|[4]Z Y Wang, et al. Mg2+ and ATP or adenosine 5'-[gamma-thio]-triphosphate (ATP gamma S) enhances intrinsic fluorescence and induces aggregation which increases the activity of spinach Rubisco activase. Biochim Biophys Acta. 1993 Sep 3;1202 (1) :47-55.|[5]Irina A Kolosova, et al. Protective effect of purinergic agonist ATPgammaS against acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2008 Feb;294 (2) :L319-24.