8-Azido-ATP (tetrasodium)

8-Azido-ATP (8-Azidoadenosine 5'-triphosphate) tetrasodium, a photoreactable nucleotide analog, is useful for the identification of proteins, such as DNA-dependent RNA polymerase. 8-Azido-ATP tetrasodium is a click chemistry reagent that contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. 8-Azido-ATP tetrasodium can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups[1][2].

Product Specifications

Product Name Alternative

8-Azidoadenosine 5'-triphosphate (tetrasodium) ; 8-N3-ATP (tetrasodium)

UNSPSC

12352005

Target

Potassium Channel

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Metabolic Disease

Solubility

10 mM in DMSO

Smiles

O[C@H]1[C@@H](O)[C@H](N2C(N=[N+]=[N-])=NC3=C(N=CN=C32)N)O[C@@H]1COP(OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O

Molecular Formula

C10H11N8Na4O13P3

Molecular Weight

636.12

References & Citations

[1]S Valenzuela, et al. Photoaffinity labeling of rotavirus VP1 with 8-azido-ATP: identification of the viral RNA polymerase. J Virol. 1991 Jul;65 (7) :3964-7. |[2]K Tanabe, et al. Direct photoaffinity labeling of the Kir6.2 subunit of the ATP-sensitive K+ channel by 8-azido-ATP. J Biol Chem. 1999 Feb 12;274 (7) :3931-3.