8-MA-NAD+ (sodium)

8-MA-NAD+ (sodium) (8-Methylamino-NAD+ (sodium) ) is a derivative of the signaling molecule and enzyme cofactor NAD+ (HY-B0445) . 8-MA-NAD+ (sodium) can be used in the screening of analog-sensitive poly (ADP-ribose) polymerase 1 (PARP1) gatekeeper mutations. 8-MA-NAD+ (sodium) can be used in the synthesis of cyclic ADP-ribose (cADPR) derivatives[1][2].

Product Specifications

Product Name Alternative

8-Methylamino-NAD+ (sodium)

UNSPSC

12352005

Target

Endogenous Metabolite

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Smiles

[O-]P(OP(OC[C@H]1O[C@@H](N2C(NC)=NC3=C(N=CN=C32)N)[C@H](O)[C@@H]1O)(O[Na])=O)(OC[C@@H]4[C@@H](O)[C@@H](O)[C@H]([N+]5=CC=CC(C(N)=O)=C5)O4)=O

Molecular Formula

C22H29N8NaO14P2

Molecular Weight

714.45

References & Citations

[1]Gibson BA, et al. Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation. Science. 2016 Jul 1;353 (6294) :45-50. |[2]Moreau C, et al. Synthesis of cyclic adenosine 5'-diphosphate ribose analogues: a C2'endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor. Org Biomol Chem. 2011 Jan 7;9 (1) :278-90.