CST651

CST651 (PROTAC CDK4/6 degrader 34) is a selective cyclin dependent kinase CDK4/6 PROTAC degrader. CST651 can degrade CDK4 and CDK6 in MM.1S cells with DC50 values of 20 and 5.1 nM. CST651 can inhibit cancer cells proliferation and migration. CST651 can be used for the research of cancer, such as acute lymphoblastic leukemia[1]. (Structure Note: Pink: CDK4/6 ligand (HY-50767) ; Blue: VHL ligand (HY-125905) ; Black: linker (HY-W017440) )

Product Specifications

CAS Number

[2489241-16-7]

Product Name Alternative

PROTAC CDK4/6 degrader 34

UNSPSC

12352005

Target

CDK; PROTACs

Related Pathways

Cell Cycle/DNA Damage; PROTAC

Field of Research

Cancer

Smiles

O=C1C(C(C)=O)=C(C2=CN=C(N=C2N1C3CCCC3)NC4=CC=C(N5CCN(CCOCCOCCOC6=CC(C7=C(C)N=CS7)=CC=C6CNC([C@H]8N(C([C@H](C(C)(C)C)NC(C9(CC9)F)=O)=O)C[C@H](O)C8)=O)CC5)C=N4)C

Molecular Formula

C56H72FN11O9S

Molecular Weight

1094.30

References & Citations

[1]Steinebach C, et al. Systematic exploration of different E3 ubiquitin ligases: an approach towards potent and selective CDK6 degraders. Chem Sci. 2020 Mar 4;11 (13) :3474-3486.