8-ET-NAD+ (sodium)
8-ET-NAD+ (sodium) is the derivative of NAD+. 8-ET-NAD+ (sodium) can be used in screening of PARP1 gatekeeper mutations. 8-ET-NAD+ (sodium) can be studied in research on cancer[1].
Product Specifications
Product Name Alternative
8-Ethylthio-NAD+ (sodium)
UNSPSC
12352005
Target
PARP
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Smiles
O=P(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H]([N+]2=CC=CC(C(N)=O)=C2)O1)([O-])OP(OC[C@@H]3[C@@H](O)[C@@H](O)[C@H](N4C5=NC=NC(N)=C5N=C4SCC)O3)(O[Na])=O
Molecular Formula
C23H30N7NaO14P2S
Molecular Weight
745.53
References & Citations
[1]Gibson, B. A., et al., (2016) . Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation. Science (New York, N.Y.), 353 (6294), 45–50.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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