8-DMA-NAD+ (sodium)
8-DMA-NAD+ (sodium) (8-Dimethylamino-NAD+ (sodium) ) is a derivative of the signaling molecule and enzyme cofactor NAD+. 8-DMA-NAD+ (sodium) can be used in the screening of analog-sensitive poly (ADP-ribose) polymerase 1 (PARP1) gatekeeper mutations[1].
Product Specifications
Product Name Alternative
8-Dimethylamino-NAD+ (sodium)
UNSPSC
12352005
Target
Endogenous Metabolite
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Smiles
O[C@H]1[C@@H](O)[C@H]([N+]2=CC=CC(C(N)=O)=C2)O[C@@H]1COP([O-])(OP(OC[C@@H]3[C@@H](O)[C@@H](O)[C@H](N4C5=NC=NC(N)=C5N=C4N(C)C)O3)(O[Na])=O)=O
Molecular Formula
C23H31N8NaO14P2
Molecular Weight
728.47
References & Citations
[1]Gibson BA, et al. Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation. Science. 2016 Jul 1;353 (6294) :45-50.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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