8-DMA-NAD+ (sodium)

8-DMA-NAD+ (sodium) (8-Dimethylamino-NAD+ (sodium) ) is a derivative of the signaling molecule and enzyme cofactor NAD+ (HY-B0445) . 8-DMA-NAD+ (sodium) can be used in the screening of analog-sensitive poly (ADP-ribose) polymerase 1 (PARP1) gatekeeper mutations[1].

Product Specifications

Product Name Alternative

8-Dimethylamino-NAD+ (sodium)

UNSPSC

12352005

Target

Endogenous Metabolite

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Smiles

O[C@H]1[C@@H](O)[C@H]([N+]2=CC=CC(C(N)=O)=C2)O[C@@H]1COP([O-])(OP(OC[C@@H]3[C@@H](O)[C@@H](O)[C@H](N4C5=NC=NC(N)=C5N=C4N(C)C)O3)(O[Na])=O)=O

Molecular Formula

C23H31N8NaO14P2

Molecular Weight

728.47

References & Citations

[1]Gibson BA, et al. Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation. Science. 2016 Jul 1;353 (6294) :45-50.