8-Br-GTP (tetrasodium)
8-Br-GTP (tetrasodium) (8-Bromoguanosine-5'-triphosphate (tetrasodium) ) is a derivative of the energy substrate – GTP, for protein synthesis and gluconeogenesis. 8-Br-GTP (tetrasodium) inhibits the E. coli GTPase FtsZ with a Ki of 31.8 μM. 8-Br-GTP (tetrasodium) promotes the assembly of porcine brain microtubules[1][2].
Product Specifications
Product Name Alternative
8-Bromoguanosine-5'-triphosphate (tetrasodium)
UNSPSC
12352005
Target
Bacterial
Related Pathways
Anti-infection
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Smiles
O=P(OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(Br)=NC3=C2NC(N)=NC3=O)O1)O[Na]
Molecular Formula
C10H11BrN5Na4O14P3
Molecular Weight
690.00
References & Citations
[1]Läppchen, T., et al., (2005) . GTP analogue inhibits polymerization and GTPase activity of the bacterial protein FtsZ without affecting its eukaryotic homologue tubulin. Biochemistry, 44 (21), 7879–7884. |[2]Muraoka, M., et al., (1999) . The effects of various GTP analogues on microtubule assembly. Cell structure and function, 24 (2), 101–109.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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