8-Br-GTP (tetrasodium)

8-Br-GTP (tetrasodium) (8-Bromoguanosine-5'-triphosphate (tetrasodium) ) is a derivative of the energy substrate – GTP, for protein synthesis and gluconeogenesis. 8-Br-GTP (tetrasodium) inhibits the E. coli GTPase FtsZ with a Ki of 31.8 μM. 8-Br-GTP (tetrasodium) promotes the assembly of porcine brain microtubules[1][2].

Product Specifications

Product Name Alternative

8-Bromoguanosine-5'-triphosphate (tetrasodium)

UNSPSC

12352005

Target

Bacterial

Related Pathways

Anti-infection

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Smiles

O=P(OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(Br)=NC3=C2NC(N)=NC3=O)O1)O[Na]

Molecular Formula

C10H11BrN5Na4O14P3

Molecular Weight

690.00

References & Citations

[1]Läppchen, T., et al., (2005) . GTP analogue inhibits polymerization and GTPase activity of the bacterial protein FtsZ without affecting its eukaryotic homologue tubulin. Biochemistry, 44 (21), 7879–7884. |[2]Muraoka, M., et al., (1999) . The effects of various GTP analogues on microtubule assembly. Cell structure and function, 24 (2), 101–109.