8-Br-dGTP (sodium)

8-Br-dGTP (8-Bromo-dGTP) sodium (Compound 5), an 8-brominated purine nucleotide, is a syn-oriented analog of dGTP. 8-Br-dGTP sodium can be hydrolyzed by the enzyme hMTH1 protein (HY-P74740) . 8-Br-dGTP sodium inhibits dGTP-activated ADP reduction with a Ki of 56 μM. 8-Br-dGTP sodium has no significant genotoxicity and mutagenic potentials during DNA synthesis[1][2][3].

Product Specifications

Product Name Alternative

8-Bromo-dGTP (sodium)

UNSPSC

12352005

Target

Nucleoside Antimetabolite/Analog

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Others

Smiles

O[C@H]1C[C@H](N2C(Br)=NC3=C2NC(N)=NC3=O)O[C@@H]1COP(OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O

Molecular Formula

C10H11BrN5Na4O13P3

Molecular Weight

674.00

References & Citations

[1]Kamiya H, et al. Probing the substrate recognition mechanism of the human MTH1 protein by nucleotide analogs. J Mol Biol. 2004 Feb 27;336 (4) :843-50. |[2]Yin Y, et al. Effects of 8-halo-7-deaza-2'-deoxyguanosine triphosphate on DNA synthesis by DNA polymerases and cell proliferation. Bioorg Med Chem. 2016 Aug 15;24 (16) :3856-61. |[3]Wu X, et al. Synthesis and biological activity of a bivalent nucleotide inhibitor of ribonucleotide reductase. Bioorg Med Chem Lett. 2000 Oct 16;10 (20) :2387-9.