8-Br-7-CH-cADPR (disodium)

8-Br-7-CH-cADPR disodium (7-Deaza-8-bromo-cADPR) is a potent cADPR antagonist. 8-Br-7-CH-cADPR disodium shows partial inhibition of calcium elevation caused by sTIR dimerization. 8-Br-7-CH-cADPR disodium significantly decreases Paclitaxel (HY-B0015) -induced axon degeneration[1].

Product Specifications

Product Name Alternative

7-deaza-8-bromo-cADPR (disodium) ; 7-deaza-8-bromo-cyclic ADP ribose (disodium)

UNSPSC

12352005

Target

Calcium Channel

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Purity

98.74

Smiles

N=C1C(C=C(Br)N2[C@H]3[C@H](O)[C@H](O)[C@@H](COP4(O[Na])=O)O3)=C2N=CN1[C@H]5[C@H](O)[C@H](O)[C@@H](COP(O4)(O[Na])=O)O5

Molecular Formula

C16H19BrN4Na2O13P2

Molecular Weight

663.17

References & Citations

[1]Yihang Li, et al. Sarm1 activation produces cADPR to increase intra-axonal Ca++ and promote axon degeneration in PIPN. J Cell Biol. 2022 Feb 7;221 (2) :e202106080.