Zatebradine (hydrochloride) (Standard)

Zatebradine (hydrochloride) (Standard) is the analytical standard of Zatebradine (hydrochloride) . This product is intended for research and analytical applications. Zatebradine (UL-FS-49 (free base) ) is a potent inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with an IC50 values 1.96 μM. Zatebradine blocks the slow inward current through human HCN1, HCN2, HCN3 and HCN4 channels, with IC50 values of 1.83 μM, 2.21 μM, 1.90 μM and 1.88 μM, respectively[1].

Product Specifications

CAS Number

[91940-87-3]

UNSPSC

12352100

Target

HCN Channel; Reference Standards

Related Pathways

Membrane Transporter/Ion Channel; Others

Field of Research

Cardiovascular Disease

Smiles

O=C1N(CCCN(CCC2=CC=C(OC)C(OC)=C2)C)CCC3=CC(OC)=C(OC)C=C3C1.Cl

Molecular Formula

C26H37ClN2O5

Molecular Weight

493.04

References & Citations

[1]Stieber J, et al. Bradycardic and proarrhythmic properties of sinus node inhibitors. Mol Pharmacol. 2006 Apr;69 (4) :1328-37. Epub 2005 Dec 30.|[2]Van Bogaert PP, et al. Use-dependent blockade of cardiac pacemaker current (If) by cilobradine and zatebradine. Eur J Pharmacol. 2003 Oct 8;478 (2-3) :161-71.