KL101

KL101, a selective cryptochrome 1 (CRY1) stabilizer, is a circadian clock modulator. KL101 can stabilize the CRY1 protein and regulate its interaction with the core feedback loop of the biological clock, thereby modulating the circadian rhythm cycle of mammals[1].

Product Specifications

CAS Number

[396721-89-4]

UNSPSC

12352005

Target

Cryptochrome

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Smiles

O=C(NC1=C2C(CSC2)=NN1C3=CC=C(C)C=C3C)C4=CC=C(C)C(C)=C4

Molecular Formula

C22H23N3OS

Molecular Weight

377.50

References & Citations

[1]Miller S, et al. Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation. Proc Natl Acad Sci U S A. 2021 Jun 29;118 (26) :e2026191118.