KL101
KL101, a selective cryptochrome 1 (CRY1) stabilizer, is a circadian clock modulator. KL101 can stabilize the CRY1 protein and regulate its interaction with the core feedback loop of the biological clock, thereby modulating the circadian rhythm cycle of mammals[1].
Product Specifications
CAS Number
396721-89-4
UNSPSC
12352005
Target
Cryptochrome
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Smiles
O=C(NC1=C2C(CSC2)=NN1C3=CC=C(C)C=C3C)C4=CC=C(C)C(C)=C4
Molecular Formula
C22H23N3OS
Molecular Weight
377.50
References & Citations
[1]Miller S, et al. Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation. Proc Natl Acad Sci U S A. 2021 Jun 29;118 (26) :e2026191118.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CRY1
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