AICAR (phosphate) (Standard)

AICAR (phosphate) (Standard) is the analytical standard of AICAR (phosphate) . This product is intended for research and analytical applications. AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR phosphate is also an autophagy, YAP and mitophagy inhibitor[1][2].

Product Specifications

CAS Number

[681006-28-0]

UNSPSC

12352100

Hazard Statement

H302, H315, H319, H335

Target

AMPK; Autophagy; Endogenous Metabolite; Mitophagy; Reference Standards; YAP

Related Pathways

Autophagy; Epigenetics; Metabolic Enzyme/Protease; Others; PI3K/Akt/mTOR; Stem Cell/Wnt

Field of Research

Cancer

Purity

99.98

Smiles

OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC(C(N)=O)=C2N)O1.O=P(O)(O)O

Molecular Formula

C9H17N4O9P

Molecular Weight

356.23

Precautions

H302, H315, H319, H335

References & Citations

[1]Nakamaru K, et al. AICAR, an activator of AMP-activated protein kinase, down-regulates the IR expression in HepG2 cells. Biochem Biophys Res Commun. 2005 Mar 11;328 (2) :449-54|[2]Drake JC, et al. AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2010 Dec;299 (6) :R1546-54.|[3]Pold R, et al. Long-term AICAR administration and exercise prevents diabetes in ZDF rats.Diabetes. 2005 Apr;54 (4) :928-34.|[4]Giri S, et al. 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase. J Neurosci. 2004 Jan 14;24 (2) :479-87.|[5]Ajaybabu V Pobbati, et al. A combat with the YAP/TAZ-TEAD oncoproteins for cancer therapy. Theranostics. 2020 Feb 18;10 (8) :3622-3635.